Devices descending from K030623
78 later devices reach Smith & Nephew Profix Total Knee System through their predicates, nearest generation first.
| Generation | Number | Device | Applicant | Decided | Own descendants | Recalls |
|---|---|---|---|---|---|---|
| +1 | K121393 | Smith & Nephew, Inc. Total Knee System Instrumentation | Smith & Nephew, Inc. | 2012 | 5 | 4 |
| +1 | K102927 | Consensus Knee System | Consensus Orthopedics, Inc. | 2011 | 0 | — |
| +1 | K100897 | Legion Porous + HA Tibial Baseplates | Smith & Nephew, Inc. | 2010 | 12 | — |
| +1 | K051229 | Profix Flex Cruciate Retaining Articular Insert | Smith & Nephew, Inc. | 2005 | 14 | — |
| +1 | K033489 | Agc Total Knee System Knee, Ascent Total Knee System, Maxim Complete Knee System, Maxim… | Biomet, Inc. | 2004 | 60 | — |
| +2 | K230653 | Smith & Nephew, Inc. ANTHEM Total Knee System, Genesis Uni Knee System, JOURNEY BCS and… | Smith & Nephew, Inc. | 2023 | 3 | 1 |
| +2 | K211221 | Porous Patella and Porous Tibia Baseplate | Smith & Nephew, Inc. | 2021 | 5 | — |
| +2 | K210554 | Physica system | Lima Corporate S.P.A. | 2021 | 2 | — |
| +2 | K173331 | JOURNEY II XR Knee Instruments | Smith & Nephew, Inc. | 2017 | 1 | 4 |
| +2 | K171054 | Biomet Knee Joint Replacement Prostheses | Biomet, Inc. | 2017 | 5 | 4 |
| +2 | K142933 | Biomet Tibial trays | Biomet, Inc. | 2014 | 6 | 3 |
| +2 | K141585 | Smith & Nephew Disposable Fin Punch | Smith & Nephew, Inc. | 2014 | 0 | — |
| +2 | K123159 | Smith & Newphew, Inc. Disposable Knee Instruments | Smith & Nephew, Inc. | 2013 | 2 | — |
| +2 | K113550 | Vanguard Complete Knee System | Biomet Manufacturing Corp | 2012 | 46 | 7 |
| +2 | K113482 | Journey II Deep Dished Articular Inserts | Smith & Nephew, Inc. | 2012 | 6 | — |
| +2 | K080361 | Regenerex Tibial Components | Biomet, Inc. | 2008 | 13 | 1 |
| +2 | K061433 | Vanguard Anatomic Patella Groove (Apg) / Vanguard V Groove | Biomet Manufacturing, Inc. | 2006 | 0 | — |
| +2 | K060303 | Vanguard PS Open Box Porous Femoral Components | Biomet Manufacturing Corp | 2006 | 47 | — |
| +2 | K041872 | Ascent Porous Open Box PS Component/Ascent Posterior Stabalized (PS) Distal Femoral Pegs | Biomet Manufacturing Corp | 2004 | 0 | — |
| +3 | K261462 | LANDMARK Total Knee System | Smith & Nephew, Inc. | 2026 | 0 | — |
| +3 | K253961 | SK Knee System | Just Medical Devices (Tianjin) Co., Ltd. | 2026 | 0 | — |
| +3 | K254084 | AETOS Shoulder System - CONCELOC Glenoids | Smith & Nephew, Inc. | 2026 | 0 | — |
| +3 | K250980 | Physica System (Physica CR Porous Femoral components) | Lima Corporate S.P.A. | 2025 | 0 | — |
| +3 | K243615 | Physica Porous Femoral Components | Lima Corporate S.P.A. | 2024 | 1 | — |
| +3 | K241260 | ACTIFY™ Unicondylar Knee System | Globus Medical, Inc. | 2024 | 0 | — |
| +3 | K242711 | JOURNEY II Unicompartmental Knee System (JOURNEY II UK) | Smith & Nephew, Inc. | 2024 | 0 | — |
| +3 | K223548 | GMK Sphere & GMK SpheriKA Cementless | Medacta International S.A. | 2023 | 1 | — |
| +3 | K221479 | Persona Personalized Knee System | Zimmer, Inc. | 2022 | 8 | — |
| +3 | K222380 | TriVerse Total Knee Replacement System | Signature Orthopaedics Pty, Ltd. | 2022 | 1 | — |
| +3 | K211671 | Journey II Mid-Level Tibial Inserts | Smith & Nephew, Inc. | 2021 | 1 | — |
| +3 | K201084 | Physica system | Lima Corporate S.P.A. | 2020 | 5 | — |
| +3 | K200227 | Journey II XR Knee Instrument | Smith & Nephew, Inc. | 2020 | 0 | — |
| +3 | K193284 | Physica LMC Knee System | Lima Corporate S.P.A. | 2020 | 6 | — |
| +3 | K190122 | Renovis A200 PS Knee System as part of the Renovis A200 Knee System | Renovis Surgical Technologies | 2019 | 1 | — |
| +3 | K183583 | Vanguard Complete Knee System | Zimmer, Inc. | 2019 | 1 | — |
| +3 | K181947 | Persona Revision Knee System | Zimmer, Inc. | 2018 | 4 | 1 |
| +3 | K180493 | A3 Total Knee System | Beijing AK Medical Co., Ltd. | 2018 | 1 | — |
| +3 | K153657 | Vanguard XP Knee System | Biomet, Inc. | 2016 | 1 | 1 |
| +3 | K152008 | Physica PS Knee System | Lima Corporate S.P.A. | 2015 | 7 | — |
| +3 | K151266 | Physica CR Knee System | Lima Corporate S.P.A. | 2015 | 8 | — |
| +3 | K143226 | Visionaire Disposable Instruments | Smith & Nephew, Inc. | 2015 | 0 | — |
| +3 | K141407 | Vanguard XP Femoral Component (Gen II)/Vanguard XP Femoral Trial | Biomet, Inc. | 2014 | 2 | 1 |
| +3 | K132873 | Vanguard XP Knee System | Biomet, Inc. | 2013 | 3 | 22 |
| +3 | K122883 | Exp Tibial Inserts and Patellar Components for the Proven Gen-Flex Total Knee System | Stelkast Company | 2013 | 4 | 1 |
| +3 | K122160 | Vanguard XP Knee System | Biomet Manufacturing Corp | 2013 | 6 | 12 |
| +3 | K101994 | Apex Knee Modular Tibia System | Omnlife Science | 2010 | 6 | 1 |
| +4 | K262057 | GMK Extension | Medacta International SA | 2026 | 0 | — |
| +4 | K262251 | ACTIFY™ Total Knee System, ACTIFY™ 3D Total Knee System (ACTIFY MC Tibial Insert) | Globus Medical, Inc. | 2026 | 0 | — |
| +4 | K251840 | Zimmer® Persona® Personalized Knee System | Zimmer, Inc. | 2026 | 0 | — |
| +4 | K253189 | Persona the Personalized Knee System (Persona Porous Plasma Spray PPS Femurs) | Zimmer, Inc. | 2026 | 0 | — |
| +4 | K253239 | Active-V Total Knee System; World Total Knee System | Signature Orthopaedics Pty, Ltd. | 2025 | 0 | — |
| +4 | K250677 | LEGION Total Knee System | Smith & Nephew, Inc. | 2025 | 0 | — |
| +4 | K243724 | Persona® Revision Knee System (Persona Revision SoluTion™ Femoral Components) | Zimmer, Inc. | 2025 | 0 | — |
| +4 | K243295 | Initia Knee System | Kyocera Medical Technologies, Inc. | 2025 | 0 | — |
| +4 | K242543 | Persona the Personalized Knee System (Persona Ti-Nidium PPS Femurs) | Zimmer, Inc. | 2024 | 0 | — |
| +4 | K240669 | ACTIFY™ 3D Total Knee System, ACTIFY™ Total Knee System | Globus Medical, Inc. | 2024 | 1 | — |
| +4 | K240299 | Persona the Personalized Knee System (Persona OsseoTi 3-Peg Patella) | Zimmer, Inc. | 2024 | 3 | — |
| +4 | K230120 | KeYi Total Knee System | Beijing Keyi Medical Device Technology Co., Ltd. | 2024 | 0 | — |
| +4 | K230321 | Persona™ Personalized Knee System | Zimmer, Inc. | 2023 | 0 | — |
| +4 | K213381 | Physica system | Lima Corporate S.P.A. | 2021 | 0 | 1 |
| +4 | K211938 | Physica LMC Knee System | Limacorporate | 2021 | 0 | — |
| +4 | K210829 | Persona Revision Knee System Femoral Metaphyseal Cones | Zimmer, Inc. | 2021 | 0 | — |
| +4 | K191625 | Persona Revision Knee System | Zimmer, Inc. | 2019 | 1 | 1 |
| +4 | K190068 | Vanguard XP Knee System | Zimmer, Inc. | 2019 | 0 | — |
| +4 | K173875 | GENFlex2 Total Knee System - Ultra-Congruent CR Tibial Insert | Stelkast, Inc. | 2018 | 2 | — |
| +4 | K162222 | GENflex2 Total Knee System | Stelkast, Inc. | 2016 | 3 | — |
| +4 | K143635 | KINETIS Total Knee System | Mako Surgical | 2015 | 0 | — |
| +4 | K140257 | Signature Planner, Signature Guides | Materialise NV | 2014 | 0 | — |
| +4 | K131472 | Apex Knee Modular Tibia System | Omni Life Science, Inc. | 2013 | 5 | — |
| +5 | K243293 | Zimmer® Persona® Personalized Knee System | Zimmer Biomet | 2024 | 1 | — |
| +5 | K243247 | Persona the Personalized Knee System | Zimmer, Inc. | 2024 | 0 | — |
| +5 | K210551 | Persona Revision Knee System | Zimmer, Inc. | 2021 | 0 | 1 |
| +5 | K153437 | Apex Revision Knee System | Omnilife Science | 2015 | 4 | 1 |
| +6 | K253637 | Triathlon® Total Knee System - Triathlon® X3® Medial Stabilized Tibial Bearing Insert | Howmedica Osteonics Corp., Dba Stryker Orthopaedics | 2026 | 0 | — |
| +6 | K163332 | Apex Revision Knee System | Omnilife Science | 2017 | 3 | — |
| +7 | K191765 | OMNI TiN Coated Apex Knee™ System | Omni Life Science, Inc. | 2019 | 2 | — |
| +8 | K252044 | Triathlon® Total Knee System - Triathlon® Gold Femoral Components | Howmedica Osteonics Corp., Dba Stryker Orthopaedics | 2025 | 0 | — |
| +8 | K201611 | Apex Knee System | Omnilife Science | 2021 | 0 | — |